David Perrais
CountryFrance
Society affiliation Société des Neurosciences
Position Principal Investigator/Group Leader
University/Organisation IINS - CNRS UMR 5297
Domain Synaptic Integration, Excitability and Plasticity
Sub domains Cellular signalling
Lab description
In the team, we address the mechanisms regulating the function of selected synapses (glutamatergic or catecholaminergic) through membrane trafficking events in normal brain physiology or in the course of disease. To achieve this goal, we use, on top of the standard techniques of the modern neuroscience lab (molecular biology, biochemistry, imaging, electrophysiology), two unique expertise developed by the two PIs: with David Perrais, we detect individual exocytosis and endocytosis events in living neurons. With Etienne Herzog, we purify selective populations of synaptosomes from adult animals with FACS and characterize them with proteomic, structural and functional assays.