Job ID: 99001

Postdoctoral Research Fellowship in Neuroscience

Position: Post-doctoral Position

Deadline: 31 May 2023

Employment Start Date: 1 September 2023

Contract Length: 2 years

City: Paris

Country: France

Institution: Center for interdisciplinary research in Biology, Collège de France



Local translation in astrocytes and radial glia

Applications are invited for a postdoctoral position to study local translation in glial cells. The focus of the project will be to characterize local translation in radial glia and in astrocytes and understand its contribution to the development of the cortex in physiology and physiopathology. Our research combines molecular approaches to characterize mRNAs and the translation machinery (Translating affinity ribosome purification;  RNA and protein immunoprecipitation; RNAseq; Mass spectrometry; qPCR…) with imaging techniques (Fluorescent in situ hybridization and immunofluorescence on brain sections) during brain development and in the adult. Candidates must have a PhD degree in neuroscience and a solid practical expertise in molecular biology. The ability to work both independently and cooperatively within a team is essential.

The appointment is for about 2 years, but candidates will be encouraged and guided to apply for additional funding opportunities.


The position is available starting from September 2022.


Candidates should send their CV, motivation letter, list of publications, and 2 letters of reference to


List of references corresponding to the project:


Oudart, M., Avila-Gutierrez, K., Moch, C., Dossi, E., Milior, G., Boulay, A.C., Gaudey, M., Moulard, J., Lombard, B., Loew, D., et al. (2022). Translational regulation by RACK1 in astrocytes represses KIR4.1 expression and regulates neuronal activity. bioRxiv 2022.07.16.500292; doi:


Boulay, A.C., Mazare, N., Saubamea, B., and Cohen-Salmon, M. (2019). Preparing the Astrocyte Perivascular Endfeet Transcriptome to Investigate Astrocyte Molecular Regulations at the Brain-Vascular Interface. Methods Mol Biol 1938, 105-116.


Mazare, N., Oudart, M., and Cohen-Salmon, M. (2021). Local translation in perisynaptic and perivascular astrocytic processes – a means to ensure astrocyte molecular and functional polarity? J Cell Sci 134.


Mazare, N., Oudart, M., Moulard, J., Cheung, G., Tortuyaux, R., Mailly, P., Mazaud, D., Bemelmans, A.P., Boulay, A.C., Blugeon, C., et al. (2020). Local Translation in Perisynaptic Astrocytic Processes Is Specific and Changes after Fear Conditioning. Cell Rep 32, 108076.


Boulay, A.C., Saubaméa, B., Adam, N., Chasseigneaux, S., Mazaré, N., Gilbert, A., Bahin, M., Bastianelli, L., Blugeon, C., Perrin, S., et al. (2017). Translation in astrocyte distal processes sets molecular heterogeneity at the gliovascular interface. Cell Discovery 3, 17005.


Mazare, N., Oudart, M., Cheung, G., Boulay, A.C., and Cohen-Salmon, M. (2020).

Immunoprecipitation of Ribosome-Bound mRNAs from Astrocytic Perisynaptic Processes of the Mouse Hippocampus. STAR Protoc 1, 100198.


Oudart, M., Tortuyaux, R., Mailly, P., Mazare, N., Boulay, A.C., and Cohen-Salmon, M. (2020). AstroDot – a new method for studying the spatial distribution of mRNA in astrocytes. J Cell Sci 133.