Job ID: 98214

MED03339-Research Associate in Circadian Biology – UK Dementia Research Institute

Position: Post-doctoral Position

Deadline: 23 November 2022

Contract Length: 1 year++

City: London

Country: United Kingdom

Institution: Imperial College London



The Brancaccio Lab invites applications from talented, highly motivated and ambitious postdoctoral scientists to lead one or more projects investigating the molecular, cellular and circuit mechanisms driving circadian dysfunction in the pre-clinical stages of Alzheimer’s disease (AD).

The projects involve using cutting-edge techniques, such as in vivo/ ex vivo viral transductions, real-time live imaging of circadian gene expression and neuronal and glial metabolic function in brain slices and in vivo, assessment of circadian and cognitive behaviour in mouse models of AD, RNA sequencing, spatial transcriptomics.

The key objectives are:

  • Investigating the role of circadian misalignment of glial and neuronal activities in AD pathogenesis
  • Investigating microglial clock function in aging and neurodegeneration
  • Exploring the role of circadian de-synchronisation in aging and neurodegenerative processes

These roles are part of the UK Dementia Research Institute at Imperial College London, located in the Department of Brain Sciences.  Postdocs in the UK DRI at Imperial enjoy excellent career development opportunities with:

  • Access to a range of cutting-edge technologies, i.e., real-time live imaging for circadian gene expression and neuronal and glial metabolic function, automated behavioural testing, single cell/nuclei transcriptomics, Imaging Mass Cytometry and computational modelling.
  • An inclusive and collegial working environment.
  • Strong national links through the UK DRI with attendance at its annual scientific meeting ‘Connectome’.
  • Support from the Postdoc and Fellows Development Centre (PFDC) and Imperial and UK DRI ECR Communities

PLease apply here: