Job ID: 96058

Post-doctoral position in molecular and cellular screening of single chain antibodies targeting G-protein-coupled receptors

Position: Post-doctoral Position

Deadline: 15 October 2022

Contract Length: 3 years

City: Tours

Country: France

Institution: Inserm U1253

Department:

Description:

Position: A three-year post-postdoctoral position is available to select and characterize pharmacologically active antibodies (VHH, nanobodies®) targeting GPCRs involved in the control of social behavior. The position is available from January 2023.

Scientific background: The research will be performed in the group “Deficits of Reward, GPRCRs and Sociability” (DRuGS – leaders: JAJ Becker and J Le Merrer) in the Team “Neuro‐functional Psychiatry” hosted at U1253 iBrain in Tours. Our research project aims at better understanding the neurobiological underpinnings of social deficit disorders, among which Autism Spectrum Disorder (ASD). We have identified A2a adenosine receptors as promising targets in ASD. The objective of the present project is to develop innovative single domain antibodies (SdAbs) inhibiting A_2AR selectively in the brain, in tight collaboration with chemists to develop antibody-drug conjugates (ADCs).

Profile: We are looking for a highly motivated post-doctoral candidate with a PhD with at least one conclusive post-doctoral experience. A background in GPCR signaling, FRET sensors and/or high throughput in vitro pharmacological screening, flow cytometry and a previous work with nanobodies will be a prerequisite. Previous experience in working with animal models (mice) will be an advantage. The candidate should display initiative, autonomy and capacity to work in a group.

Please send a letter of interest, a full CV, and the coordinates of 3 referees to Jérôme Becker (jerome.becker@inserm.fr) before October 15^th 2022.