Job ID: 86948

Post-doctoral fellow positions in myelin biology and disease

Position: Post-doctoral Position

Deadline: 31 October 2022

Employment Start Date: 1 November 2022

Contract Length: 3 years

City: Milano

Country: Italy

Institution: San Raffaele Scientific Institute

Department: Division of Neuroscience

Description:

The San Raffaele Scientific Institute, which includes the Hospital and University, is a biomedical campus at the forefront in many biomedical areas and provides the best assistance to its patients, thanks to the integration of basic, translational and clinical research, https://research.hsr.it/en/index.html. Research work in the Human Inherited Neuropathies Unit at the San Raffaele Scientific Institute integrates basic and preclinical research through a translational approach, with a focus in:

i) understanding pathogenetic mechanisms underlying inherited peripheral neuropathies, thus also unravelling key signals and pathways regulating myelination in Schwann cells and axons (for reference, Bolino, Myelin Biology. Neurotherapeutics, 2021)

ii) validating therapeutic approaches to treat these disorders in partnership with patient associations and companies. The lab is also interested in identifying potential disease biomarkers using transcriptomics and proteomics strategies.

Candidates will contribute to the following projects aimed at:

1- Further clarifying how lipid-mediated cytoskeleton remodeling and myelin synthesis control myelin growth in the nerve. These mechanisms are of clinical relevance as these pathways represent targets for pharmacological intervention to treat inherited peripheral neuropathies (Guerrero-Valero et al., PNAS 2021; Sawade et al., Nature Communications, 2020).

2- Assessing efficacy, including disease biomarkers responsiveness, of AAV9-mediated gene therapy to replace enzymes lost in severe forms of inherited peripheral neuropathies characterized by myelin and axon degeneration.

Profile

We are looking for highly motivated candidates with a strong background and consolidated research experience in cell biology and neuroscience. Ability to work in team, research planning and organization, and communication skills are expected.

Job offer

Full time contracts up to three years. Opportunity to work in a biomedical campus where bio-medicine research, practice and training interact on a daily basis.

How to apply

Applicants should send their CV, research statement, and contact information of at least tow academic references to Prof. Alessandra Bolino, bolino.alessandra@hsr.it.