Job ID: 85085

Post doc positions in Nervous System Tumors

Position: Post-doctoral Position

Deadline: 7 August 2022

Employment Start Date: 1 December 2022

Contract Length: 2-6 years

City: Stockholm

Country: Sweden

Institution: Karolinska

Department: MTC


Our Research focus:

Cancer risk increase with age because cancer is viewed as a multistep process involving mutation and selection for cells with progressively increasing capacity for proliferation, survival, invasion, and metastasis.
But why does childhood cancer exist if cancer is a multi-step progression requiring long period of time to develop?


Our lab focusses on childhood neuroblastoma:
We explore the cellular origin of pediatric nervous system cancer, its developmental roots, and how it is linked to embryogenesis. Understanding how the sympathetic nervous system is shaped during development will give us important clues how neuroblastoma arises and what are the driving forces of its remarkable heterogeneity and phenotypic plasticity.


We are seeking a motivated, creative post-doctoral candidate interested in tumor mouse models

arising from the sympatho-adrenal lineage, such as neuroblastoma and pheochromocytoma, with

the aim to understand the molecular principles of these tumors at a previously unprecedented



Furthermore, we are looking for motivated, creative post-doctoral candidates interested in cancer metabolism with knowledge in basic biochemistry and molecular biology. We currently defning how oxygen sensing regulates mitochondrial dynamics and mass.

check out our latest paper:

Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome.

Li S, Li W, Yuan J, Bullova P, Wu J, Zhang X, Liu Y, Plescher M, Rodriguez J, Bedoya-Reina OC, Jannig PR, Valente-Silva P, Yu M, Henriksson MA, Zubarev RA, Smed-Sörensen A, Suzuki CK, Ruas JL, Holmberg J, Larsson C, Christofer Juhlin C, von Kriegsheim A, Cao Y, Schlisio S. Nat Metab. 2022 Jun;4(6):739-758. doi: 10.1038/s42255-022-00593-x. Epub 2022 Jun 27.


In addition, we are looking for one outstanding researcher to work on the computational analyses of a large-scale single-cell transcriptome project on neuroblastoma. In this project we will generate “molecular encyclopedias” of this tumor in order to understand the molecular principles concerning the origin, progression and subtypes of this tumor at a previously unprecedented level, using state-of-the-art RNA-seq and bioinformatics technologies. Therefore, we seek one postdoctoral research fellow with expertise in computational analyses of RNA-seq data and OMICS data.

check out our latest papers:

Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors.

Bedoya-Reina OC, Li W, Arceo M, Plescher M, Bullova P, Pui H, Kaucka M, Kharchenko P, Martinsson T, Holmberg J, Adameyko I, Deng Q, Larsson C, Juhlin CC, Kogner P, Schlisio S.Nat Commun. 2021 Sep 7;12(1):5309. doi: 10.1038/s41467-021-24870-7.

Chromaffin Cells with Sympathoblast Signature: Too Similar to Keep Apart?

Bedoya-Reina OC, Schlisio S.Cancer Cell. 2021 Feb 8;39(2):134-135. doi: 10.1016/j.ccell.2020.12.009. Epub 2020 Dec 31.


Application process:

An employment application must contain the following documents in English: A complete

curriculum vitae, including date of the thesis defense, title of the thesis, previous academic

positions, academic title, current position, academic distinctions, and committee work

1. A CV including complete list of publications

2. A summary of current work (no more than one page) and your research interests

3. 2 reference letters

Please send your application Susanne Schlisio via :