Job ID: 84844
PhD position : Signatures of plasticity in dorsal striatum during procedural learning
Position: Ph.D. Student
Deadline: 10 September 2022
Employment Start Date: 1 October 2022
Contract Length: 3 years
Institution: Collège de France
Department: Center for interdisciplinary biology
Laurent Venance’s lab (https://venancelab.wordpress.com/) is recruiting a highly-motivated student for a PhD. The main subject of the project will be focus on the signatures of plasticity in dorsal striatum during procedural learning. Using 2-photon calcium imaging at the network and subcellular levels in behaving mice, we will dissect the synaptic landscape dynamics used to accommodate novelty learning in dorsal striatum. We already identified that during motor-skill learning dorsal striatum expresses region-specific plasticity (Perez S, et al. Cell report 2022). The project aims at linking how distinct plasticity signatures could endow dorsal striatum with complementary capacities in memory acquisition and stabilization.
The successful candidate should be highly motivated to contribute to our efforts on dissecting mechanisms of neural circuit and synaptic plasticity at play during procedural learning and novelty experience. The candidate is expected to take a leading role in 2-photon imaging experiments (data acquisition and analysis), aligned with plasticity and behavioral performance. Experience with 2-photon imaging, electrophysiology, data analysis and programming experience are a significant plus.