Job ID: 84545

Postdoctoral Associate- Genetics and Circuitry of Sleep

Position: Post-doctoral Position

Deadline: 16 September 2022

Employment Start Date: 1 September 2022

Contract Length: 5 years

City: Baltimore

Country: United States

Institution: Johns Hopkins University

Department: Neurology

Description:

Postdoctoral Associate- Genetics and Circuitry of Sleep

A postdoctoral associate position is available to study the molecular and circuit basis of sleep.  We use sophisticated genetic approaches in Drosophila and mice to study the genes and circuitry underlying sleep, a fundamental and evolutionary conserved behavior.  We are studying the homeostatic and circadian mechanisms regulating sleep, and also have deep interest in understanding the functions of sleep.  To carry out these studies, we combine molecular and genetic approaches with high throughput behavioral assays, immunohistochemical techniques, patch-clamp electrophysiology, and in vivo functional imaging.  Applicants should have a Ph.D. and/or M.D. and be creative and highly motivated.  A strong background in electrophysiology is desirable.  For more information, please visit our website:  www.markwulab.net.

Representative publications:

1. Blum, I.D.*, Keles, M.F.*, Baz, E.-S., Han, E., Park, K., Luu, S., Issa, H., Brown, M., Ho, M.C.W., Tabuchi, M., Liu, S.*, and Wu, M.N.*(2021).  Astroglial Calcium Signaling Encodes Sleep Need in Drosophila.  Curr Biol 31, 150-162.
2. Tabuchi, M., Monaco, J.D., Duan, G., Bell, B., Liu, S., Liu, Q., Zhang, K., andWu, M.N. (2018).  Clock-Generated Temporal Codes Determine Synaptic Plasticity to Control Sleep.  Cell 175, 1-15.
3. Liu, Q*., Tabuchi, M.*, Liu, S., Kodama, L., Horiuchi, W., Daniels, J., Chiu, L., Baldoni, D., and Wu, M.N. (2017). Branch-Specific Plasticity of a Bifunctional Dopamine Circuit Encodes Protein Hunger.  Science 356, 534-539.
4. Liu, S.*, Liu, Q.*, Tabuchi, M., and Wu, M.N. (2016). Sleep Drive is Encoded by Neural Plastic Changes in a Dedicated Circuit.  Cell 165, 1347-1360.
5. Liu, S.*, Lamaze, A.*, Liu, Q., Tabuchi, M., Yang, Y., Fowler, M., Bharadwaj, R., Zhang, J., Bedont, J., Blackshaw, S., Lloyd, T.E., Montell, C., Sehgal, A., Koh, K.*, and Wu, M.N.* (2014). WIDE AWAKE Mediates the Circadian Timing of Sleep Onset.  Neuron 82, 151-166.

Please send cover letter, CV, and the names of three references to marknwu@jhmi.edu.