Job ID: 83359

PhD in light sheet microscopy of cleared human tissue

Position: Ph.D. Student

Deadline: 1 September 2022

Employment Start Date: 1 October 2022

Contract Length: 3-4 years

City: Vienna

Country: Austria

Institution: TU Wien

Department: Bioelectronics


Applications are invited for a PhD (3 – 4 years) at the Institute of Solid State Electronics, Dept. of Bioelectronics at TU Vienna with additional affiliation to the Center for Brain Research, Section of Bioelectronics, MedUni Vienna.Research group

We are a group pioneering application and development of light sheet microscopy since over a decade (Dodt et al.,Nature Methods 2007). In the last years we started to apply light sheet microscopy to the 3D imaging of human tumors. We are developing both advanced optics and clearings for this new field of research. We are convinced that 3D pathology will revolutionize histological diagnostics and are looking for a PhD student for the application of light sheet microscopy to several types of human tumors.

Possible tasks

    • Application of light sheet microscopy to seveal types of tumors obtained from cancer operations (breast, colon, brain etc.) and also larger pieces of normal human brain
    • Improvement and development of fast and efficient clearings
    • Improvement and development of specific stainings to simulate standard histology in 3D and other tissue compartments
    • Development of immunohistological staining for bulk tissue
    • Development of optics for large cleared tissue pieces
    • Data handling and stitching of large imaging files


We are seeking for a student with graduation in medicine, biology, chemistry, physics or related fields. Expertise in histology and staining techniques would be highly welcome. Also experience in optical physics and data handling would be a plus. As we are a very interdiscipinary research group expert knowledge and support in the above mentioned research fields is available.

To apply send an email including a short letter of motivation, CV and references to  (Prof. Hans-Ulrich Dodt). Funding is provided by a new grant of the FWF (Austrian science funding agency) with salary based on 30h/week (PhD) according to FWF policies.