Job ID: 103338

PhD student position (m/f/d) in molecular mechanisms of learning and memory

Position: Ph.D. Student

Deadline: 31 March 2023

City: Mannheim

Country: Germany

Institution: Central Institute of Mental Health

Department: Department of Molecular and Cellular Cognition Research

Description:

The Department for Molecular and Cellular Cognition Research, at the Central Institute of Mental Health (Mannheim, Germany) offers a:

PhD student position (m/f/d) in molecular mechanisms of learning and memory

Our group investigates the molecular mechanisms that underlie the formation and maintenance of memories. We focus on the transcriptional and epigenetic regulation of gene expression that is critical for the stabilization of memories for long periods of time. The successful candidate will investigate the transcriptional and epigenetic mechanisms in learning and memory as well as study the underlying causes of cognitive deficits in pathological conditions. The project will use a multidisciplinary approach that combines molecular and behavioral techniques and viral vectors to modulate the expression of target genes. The Heidelberg/Mannheim region is a scientific hub that houses several internationally renowned research institutes with research groups committed to study Neuroscience at various levels. This region further offers access to several state-of-the-art core facilities.

Employment, payment and social benefits are according to the German salary scale TV-L E13 (65%). The position is funded for three years and is expected to start at the earliest possible date.

The candidate should be highly motivated, with good interpersonal and communication skills and show willingness to work in an international environment (working language is English). The candidate should hold a Masters (or equivalent) degree in Biology, Biochemistry or Neuroscience. He/She should have a strong background in molecular and cell biology and previous experience with animal handling (FELASA) would be an advantage but not mandatory.

For more information on our lab see www.oliveiralab.weebly.com.

Applications must be submitted via the HBIGS website – PhD project with reference “Oliveira_2023”.

(http://www.hbigs.uni-heidelberg.de/main_application.html)

References:

Gulmez Karaca K, Kupke J, Brito DCV, Zeuch B, Thome C, Weichenhan D, Lutsik P, Plass C, Oliveira AMM (2020) Neuronal ensemble-specific DNA methylation strengthens engram stability. Nature Communications. 11(1):639

Brito DCV, Kupke J, Gulmez Karaca K, Zeuch B, Oliveira AMM (2020) Mimicking age associated Gadd45g dysregulation results in memory impairments in young adult mice. Journal of Neuroscience. 40(6):1197-1210

Oliveira AMM, Hemstedt TJ and Bading H (2012) Rescue of aging-associated decline in Dnmt3a2 restores cognitive abilities. Nature Neuroscience 15(8): 1111-1113

Gulmez Karaca K, Kupke J, Oliveira AMM (2021) Molecular and cellular mechanisms of engram allocation and maintenance. Brain Research Bulletin. 170:274-282 [Review]

Oliveira AMM (2016) DNA methylation: a permissive mark in memory formation and maintenance. Learning and Memory 23(10):587-593 [Review]