Job ID: 6089

Ph.D. Student in Freiburg/Germany

Position: Ph.D. Student

Deadline: 1 June 2021

City: Freiburg

Country: Germany

Institution: University Medical Center Freiburg

Department:

Description:

The search for mechanistically novel and more effective therapeutic options for depression is currently a research priority. We have identified that the synaptic plasticity protein Homer1a, as a modulator of glutamatergic signalling, is an important element for the antidepressant therapy. We aim to further characterize the role of glutamatergic and dopaminergic signaling in the mechanism of action of rapid antidepressant treatments and deep brain stimulation.
Holz A, Mülsch F, Schwarz MK, Hollmann M, Döbrössy MD, Coenen VA, Bartos M, Normann C, Biber K, van Calker D, Serchov T*. (2019) Enhanced mGlu5 Signaling in Excitatory Neurons Promotes Rapid Antidepressant Effects via AMPA Receptor Activation. Neuron. pii: S0896-6273(19)30637-3. doi: 10.1016/j.neuron.2019.07.011.
The project combines molecular biology techniques with in vivo behavioral characterization and fiberphotometry. Therefore a suitable candidate should have a Master degree in Neuroscience/Biology/Medicine or related field as well as experience and practical skills in one or more of the following fields: SDS-PAGE and western blot; qRT-PCR gene analyses; basic skills in in vivo stereotactic surgery, electrode/cannula implantation and intracerebral viral microinjections in rodents; basic knowledge of MathLab analyses; different behavioral tests in mice.
Applications, preferably in one single PDF-document, including a complete CV, publication list, letter of motivation (half page) with a brief statement of the previous research experience related to the field and scientific interests, copy of relevant certificates and names and contacts of two references should be sent electronically to tsvetan.serchov@uniklinik-freiburg.de (Dr. Tsvetan Serchov).

 

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