Job ID: 5415

Several positions in therapy for neuromuscular diseases (Postdoc, engineers) in Lyon/France

Position: Post-doctoral Position

Deadline: 31 March 2021

Contract Length: 3 years

City: Lyon

Country: France

Institution: Inserm - NeuroMyoGene institute

Department: Neuroscience

Description:

In the « Therapy for Giant Axonal Neuropathy» project, the Bomont laboratory, and the partner Puccio are seeking highly motivated candidates in the development of therapy for neuromuscular diseases.

Science. Bomont laboratory has a long-lasting expertise in the fatal neuromuscular disease called Giant Axonal Neuropathy (GAN). The team identified the defective gene, which encodes for the Gigaxonin-E3 ligase and modelized the disease in mouse and zebrafish, to unravel pivotal roles of Gigaxonin in cytoskeleton architecture, autophagy maturation and motoneuron specification. With robust animal models in hands, and the identification of therapeutic candidates, the team aims to conduct a dual preclinical study for GAN: using pharmacological and gene therapy approaches. This translational project will benefit from the expertise of the Puccio team, which succeeded in developing gene therapy programs for Friedreich Ataxia.

Profiles. 3-year positions for 1 postdoctoral researcher (Bomont) and 2 engineers (Bomont & Puccio); will work in close collaboration with other members of the teams. Mandatory for all: curious, enthusiastic & team player; prior experience with mice. Postdoc expertise: neurobiology of the mouse with a strong knowledge in histopathology. Engineer 1 expertise: at the interface between zebrafish & mouse; zebrafish experience is an asset but not mandatory; skills required in histopathology. Engineer 2 expertise: skills in molecular biology techniques; immunofluorescence and histopathology are assets but not required. French speaking is NOT a requirement.

When/how to apply. Starting date ideally in mid 2021, but we will accommodate the selected candidates. Please send your application in a SINGLE 3 page-long pdf, including you CV, summary of your previous research experiences, and contact information of 2-3 references.

For more details, please visit our website and download the pdf of the offers.

Previous job ID: 28414