Job ID: 5393

Post-doctoral position in Milan/Italy

Position: Post-doctoral Position

Deadline: 30 June 2021

Contract Length: 3 years

City: Milan

Country: Italy

Institution: IRCCS Ospedale San Raffaele

Department: Division of Neuroscience

Description:

A post-doctoral position is available in the Prof. Bolino laboratory at the IRCCS Ospedale San Raffaele, Milan, Italy. The IRCCS Ospedale San Raffaele is a university and research hospital at the forefront in many biomedical areas established to provide the best assistance to patients, thanks to the integration of basic, translational and clinical research (http://research.hsr.it/en/our-mission.html).

Research in our laboratory follows a multidisciplinary approach including genetics, biochemistry, and cell biology and seeks to i) identify new genes responsible for inherited peripheral neuropathies and lower motor neuron diseases; ii) elucidate how defects in these genes provoke human diseases; and iii) exploit these mechanisms to design therapeutical strategies to ameliorate PNS diseases.

In particular, the post-doctoral candidate will assess how phosphoinositides coordinate mTORC1-dependent myelin synthesis and acto-myosin cytoskeletal dynamics to promote myelin membrane expansion and growth. The candidate will also identify additional phosphoinositide effectors in neurons/Schwann cells, thus contributing to understand how myelination is achieved and regulated. These effectors represent potential targets for pharmacological intervention to treat inherited peripheral neuropathies like Charcot-Marie-Tooth disease (see for example: Sawade et al., Nat Comm 2020).

We are looking for highly motivated applicants who wish to advance in their academic training and consolidate the research experience in cell biology and neuroscience.
Previous research experience in cell biology and/or molecular biology is required.

Selection process
Please send your application including a synopsis of research interest, Curriculum vitae, and at least two contacts for reference in a single pdf file to:
Alessandra Bolino, bolino.alessandra@hsr.it

 

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