Job ID: 5371

Post-doctoral position in Limoges/France

Position: Post-doctoral Position

Deadline: 15 May 2021

Contract Length: 1 year

City: Limoges

Country: France

Institution: EA6309 Myelin Maintenance & Peripheral Neuropathies

Department:

Description:

Curcumin has shown beneficial effects in different models of peripheral neuropathies. Nevertheless, curcumin is a molecule with low solubility and poor bioavailability, which considerably limits its therapeutic use. Recently, we have shown that the delivery of curcumin trough a nanoparticle vector significantly reduces the deficits of transgenic rats reproducing the physiopathology of Charcot-Marie-Tooth type 1A (CMT1A) disease, the main hereditary peripheral neuropathy. The aim of this research project is to confirm the effectiveness of this nanoparticle formulation of curcumin in the treatment of CMT1A disease.

The research work will take place within the EA6309 research lab, in close collaboration with a Ph.D. student. Some experiments will be performed in vitro (primary cultures of Schwann cells, neurons and co-cultures). The effectiveness of the curcumin nanoparticle formulation will be confirmed in vivo. Behavioural (locomotion, equilibrium, grip strength) and electro-physiological (nerve conduction velocity) experiments will be carried out in combination with morphological, immunohistochemical and biochemical analyses.

The candidate should have a Ph.D. in Neuroscience and skills in behavioural analysis in rodents (rat/mice). Experience in electromyoneurography (EMNG) would be appreciated. Motivation, dynamism and writing skills will also be considered.

Send CV (including a short summary of previous research work), motivation letter and contact details of at least 2 references to: fabrice.billet@unilim.fr

Previous job ID: 28282