Job ID: 5227
Post-doctoral position in Leipzig/Germany
Position: Post-doctoral Position
Deadline: 31 August 2021
Institution: Helmholtz Zentrum München
Department: Helmholtz-Institut für Metabolismus-, Adipositas- und Gefäßforschung (HI-MAG)
The newly founded Young Investigator Group “Diet-Induced Metabolic Alterations” headed by Dr. Alexander Jais is looking for a highly motivated
Postdoc (f/m/x) in Neuronal Regulation of Energy Homeostasis at the YIG “Diet-Induced Metabolic Alterations”
In the YIG “Diet-Induced Metabolic Alterations”, we use different genetic mouse models to decipher the molecular and genetic underpinnings of obesity development. The consumption of palatable, energy-dense food facilitates overeating via central nervous system (CNS)-dependent mechanisms. Circulating nutrients, metabolites and hormones, released by peripheral organs such as adipose tissue, liver, pancreas and the gastrointestinal tract act as homeostatic feedback signals to the CNS, which implements appropriate behavioral and metabolic responses in order to maintain energy and metabolic homeostasis.
Our lab’s research is focused on providing detailed insights into neurocircuitries activated by palatable, energy-dense food. We are using molecular and systems neuroscience approaches to define the anatomical distribution, molecular signature and neurocircuitry architecture of these neurons (for example: https://pubmed.ncbi.nlm.nih.gov/32302532/). Furthermore, we want to investigate the longitudinal effects governed by these neurons to determine their physiological relevance and their role in the deregulation of whole-body energy and metabolic homeostasis. The ultimate goal of this research is to develop novel noninvasive therapeutic interventions for obesity and other prevalent metabolic disorders.
PNOC ARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding – PubMedCalorie-rich diets induce hyperphagia and promote obesity, although the underlying mechanisms remain poorly defined. We find that short-term high-fat-diet (HFD) feeding of mice activates prepronoci…anzeigenvorschau.net
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