Job ID: 5227

Post-doctoral position in Leipzig/Germany

Position: Post-doctoral Position

Deadline: 31 August 2021

City: Leipzig

Country: Germany

Institution: Helmholtz Zentrum München

Department: Helmholtz-Institut für Metabolismus-, Adipositas- und Gefäßforschung (HI-MAG)


The newly founded Young Investigator Group “Diet-Induced Metabolic Alterations” headed by Dr. Alexander Jais is looking for a highly motivated

Postdoc (f/m/x) in Neuronal Regulation of Energy Homeostasis at the YIG “Diet-Induced Metabolic Alterations”

Your responsibilities

In the YIG “Diet-Induced Metabolic Alterations”, we use different genetic mouse models to decipher the molecular and genetic under­pinnings of obesity develop­ment. The consumption of palatable, energy-dense food facilitates overeating via central nervous system (CNS)-dependent mechanisms. Circu­lating nutrients, meta­bolites and hormones, released by peri­pheral organs such as adipose tissue, liver, pancreas and the gastro­intestinal tract act as homeo­static feedback signals to the CNS, which implements appro­priate behavioral and meta­bolic responses in order to maintain energy and meta­bolic homeo­stasis.

Our lab’s research is focused on providing detailed insights into neuro­circuitries activated by palatable, energy-dense food. We are using molecular and systems neuro­science approaches to define the anato­mical distri­bution, molecular signature and neuro­circuitry archi­tecture of these neurons (for example: Furthermore, we want to investi­gate the longitudinal effects governed by these neurons to determine their physio­logical relevance and their role in the deregu­lation of whole-body energy and metabolic homeo­stasis. The ultimate goal of this research is to develop novel non­invasive thera­peutic inter­ventions for obesity and other preva­lent metabolic disorders.

PNOC ARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding – PubMedCalorie-rich diets induce hyperphagia and promote obesity, although the underlying mechanisms remain poorly defined. We find that short-term high-fat-diet (HFD) feeding of mice activates prepronoci…

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