We are looking for motivated candidates with an interest in the fields of neurophysiology, neurobiology, and neurodegeneration. The project aims at investigating the mechanisms underlying the breakdown of homeostatic scaling between synaptic excitation and motoneuron excitability in mice displaying Amyotrophic Lateral Sclerosis. To meet these aims we will implement cutting-edge methods combining intracellular recordings of mouse spinal motoneurons in vivo, with advanced chemogenetics, viral manipulations and molecular biology. The candidate will be responsible for performing in vivo electrophysiological investigations in anaesthetized mice (intracellular recordings of spinal motoneurons) after genetic manipulations. S/he will also participate in virus injections and immunohistochemical analysis It should be noted that s/he will be trained by the project PI’s, which are world leaders of the mouse in vivo intracellular electrophysiology, for an approximate time period of 6 months in order to be fully operational. Upon completion of this training, the successful candidate will be part of the small group of electrophysiologists with this rare expertise of paramount importance. The project will be made in collaboration with Prof. Francesco Roselli at Ulm University (Germany) who will provide scientific know-how for the virus engineering and the molecular biology component of the project.
The candidate should have solid experience in electrophysiology and good knowledge of cell biology. Working language is English and fluency in this language is required.
The successful candidate will start as soon as possible.
Interested candidates are welcome to ask for more details and to send their CV, short introduction letter, and two reference letters to firstname.lastname@example.org and Daniel.Zytnicki@parisdescartes.fr
The position is funded by the Polish National Science Centre with a very attractive gross annual salary of 120 000 PLN, significantly exceeding the Polish average.