Job ID: 12579

Ph.D. Student in Uppsala/Sweden

Position: Ph.D. Student

Deadline: 20 May 2021

Employment Start Date: 1 September 2021

Contract Length: 4 years

City: Uppsala

Country: Sweden

Institution: Uppsala University

Department: Organism Biology/Comparative Physiology


This PhD student position is available in Åsa Mackenzie´s (Wallén-Mackenzie) research group where research is focused on neurocircuitry analysis of the subthalamic nucleus and surrounding brain structures of importance to motor, affective and associative functions. Our research is centered around uncovering neurobiological underpinnings of the network in which the subthalamic nucleus acts. Which neurons control movement, which ones regulate emotions? We use mouse transgenics and optogenetics to achieve high precision when unraveling brain pathways and their involvement in behavioral regulation. In addition to in vivo-studies, molecular biology and histology are important techniques. Our group is international and English is the language most commonly used.

Project description: The subthalamic nucleus (STN) is a clinically important area but basic neurobiological knowledge is largely missing. Dysregulated activity of the subthalamic nucleus is strongly associated with several neurological and neuropsychiatric disorders, such as Parkinson´s disease and compulsive disorders, and stimulations of this nucleus aim at their treatment. However, it remains to fully uncover how the subthalamic area and its neurocircuitry is engaged in brain function and behavioral regulation. This, in turn, is important both to better understand brain physiology under normal circumstances and how to better prevent and treat brain disorders.

This PhD project aims at decoding the subthalamic nucleus and its neurocircuitry both anatomically and functionally using viral-genetic methods, histology, molecular methods, and behavioral assessment.

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