Job ID: 12573

Post-doctoral position in Paris/France

Position: Post-doctoral Position

Deadline: 1 October 2021

Contract Length: up to 3 years

City: Paris

Country: France

Institution: Zugaro Lab, Collège de France

Department: CIRB

Description:

Two post-doctoral positions are available to investigate the network mechanisms of memory formation and consolidation in the Zugaro lab (http://zugarolab.net), hosted in the Center for Interdisciplinary Research for Biology at the Collège de France, in the historic centre of Paris. Our team is characterized by a diversity of backgrounds (biology, engineering) and a friendly atmosphere.

To investigate how the fast timescale dynamics of brain activity mediate cognitive functions, we record from distributed neuronal ensembles during behavior and sleep. We have shown that the formation of new memories requires the activation of fast sequences of hippocampal assemblies paced by theta oscillations [1-2]. Subsequent replay of the same sequences during sleep ripples mediates a hippocampo-cortical dialogue also involving delta waves and spindles and is instrumental for memory consolidation [3-7]. An unexpected role of delta waves is to isolate an ever-changing minority of cortical assemblies involved in memory consolidation [8].

One candidate should have a strong background in recordings of large neuronal ensembles and optogenetics in freely behaving rodents. Good Matlab programming skills are welcome.

The other candidate should have a solid background in data analysis of brain signals. Experimental training would also be extremely useful.

Both positions are available for up to 3 years. Selection will be open until the positions are filled. Applicants should send their CV, a cover letter detailing their research experience and interests, and two letters of reference.

1 Drieu et al. (2018) Science 362:675-9
2 Cei et al. (2014) Nature Neuroscience 17:719-24
3 Girardeau et al. (2009) Nature Neuroscience 12:1222-3
4 Peyrache et al. (2009) Nature Neuroscience 12:919-26
5 Benchenane et al. (2010) Neuron 66:921-36
6 Girardeau et al. (2014) Journal of Neuroscience 34:5176-83
7 Maingret et al. (2016) Nature Neuroscience 19:959-64
8 Todorova and Zugaro (2019) Science 366:377-81

previous job ID: 28837