Job ID: 12568

Ph.D. Student in Innsbruck/Austria

Position: Ph.D. Student

Deadline: 1 October 2021

City: Innsbruck

Country: Austria

Institution: Medical University of Innsbruck

Department: Institute of Molecular and Cellular Pharmacology

Description:

Calcium channels in regulation of dendritic complexity.

In the central nervous system L-type voltage-gated calcium channels are prominently involved in regulation of dendritic complexity. However, the underlying signaling pathways and their regulation are surprisingly underexplored. An increasing body of evidence shows that calcium channels are involved in psychiatric disorders, intellectual disabilities, and ageing, all conditions characterized by the remodeling of the dendritic arbor. Ongoing results in our laboratory suggest that channel phosphorylation is intriguingly a key regulator of dendritic complexity. This project aims at understanding the channel phosphorylation dependent cellular biology underpinning dendritic complexity in hippocampal neurons.
Methods: Primary culture of hippocampal neurons, cell culture, calcium imaging and fluorescent microscopy of synapses and dendritic development, immunofluorescence, whole cell electrophysiology, calcium signaling analysis via pharmacological treatments and transient transfection of dominant negative or constitutively active kinases.

References: Folci et al. (2018), J Biol Chem 293(3):1040-1053; Etemad et al (2014) 34(4):1446-61; Di Biase et al. (2011) 31(38):13682-94; Di Biase et al. (2008) 28(51):13845-55
Salary: According to the rates of the Austrian Science Fund (FWF) for PhD students plus travel funds for international scientific meetings.

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