Job ID: 12541

Post-doctoral position in Nijmegen/Netherlands

Position: Post-doctoral Position

Deadline: 17 May 2021

Employment Start Date: 1 July 2021

Contract Length: 3 years

City: Nijmegen

Country: Netherlands

Institution: Max Planck Institute for Psycholinguistics

Department: Language and Genetics Department


A 3-year postdoctoral position on Modeling Gene Disruptions in Human Neurons is available within the Language & Genetics Department at the Max Planck Institute, Nijmegen, the Netherlands. The department is led by Simon Fisher, co-discoverer of FOXP2, the first gene to be implicated in a speech and language disorder. Through whole genome DNA sequencing, we have identified rare gene disruptions that cause speech and language impairments in human neurodevelopmental disorders.
The successful candidate will lead specific projects within an ongoing research programme that investigates the neurobiological consequences of such gene disruptions (in FOXP1/2/4, CHD3, SETBP1 among other genes). This programme adopts the latest human cell-culture techniques (stem-cell derived 2D and 3D neuronal models), CRISPR/Cas-based gene editing, single-cell RNA sequencing, and other state-of-the-art methods. The work is carried out in a custom-built molecular biology laboratory at the Max Planck Institute, which has its own cell-culture facilities, an advanced microfluidics system for high-throughput single-cell analyses, and dedicated histology and microscopy suites, including a confocal microscope with live cell-imaging capabilities. These resources are complemented by bioinformatic experts within the department, excellent in-house infrastructure for data analysis supported by a central technical group, and close collaborative links with the Human Genetics department of Radboudumc, on the same campus.

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previous job ID: 28796