Job ID: 12527

Ph.D. Student in Homburg-Saar/Germany

Position: Ph.D. Student

Deadline: 31 May 2021

Employment Start Date: 1 July 2021

Contract Length: Initially 2 years, with possible extensions

City: Homburg-Saar

Country: Germany

Institution: University of Saarland

Department: CIPMM, Physiology


A Ph.D. position is available to study the molecular mechanisms that mediate neuronal exocytosis. The challenge is to define the molecular events that couple Ca2+ signalling to fusion of synaptic vesicles with the plasma membrane. We are addressing this issue using state-of-the-art electro-physiological methods (carbon fiber amperometry and membrane capacitance measurements), imaging techniques (Fura measurements, photolytic ‘uncaging’ of Ca2+, confocal microscopy, structured illumination and STED microscopy) and mice strains that are genetically deficient for synaptic proteins in order to discover, characterize, and disrupt protein-protein interactions that operate in excitation-secretion coupling. The work is directly supported by technical personnel and applicants are given the opportunity to extend their research interest internationally through project–oriented collaborations. Applicants with experience in electrophysiology, molecular biology, fluorescence spectroscopy are especially encouraged to apply.
Please send your application including curriculum vitae, list of publications and a brief statement of research interest to Prof. Dr. Dieter Bruns.Selected readings:
Dhara M, Mantero Martinez M, Makke M, Schwarz Y, Mohrmann R, Bruns D. Synergistic actions of v-SNARE transmembrane domains and membrane-curvature modifying lipids in neurotransmitter release. Elife. 2020
Schwarz Y, Oleinikov K, Schindeldecker B, Wyatt A, Weißgerber P, Flockerzi V, Boehm U, Freichel M, Bruns D. TRPC channels regulate Ca2+-signaling and short-term plasticity of fast glutamatergic synapses. PLoS Biol. 2019,17.
Schwarz Y, Zhao N, Kirchhoff F, Bruns D. Astrocytes control synaptic strength by two distinct v-SNARE-dependent release pathways. Nat Neurosci. 2017,20, see Faculty of 1000.

previous job ID: 28771

Phone: +49 6841-1616495,+49 6841-1616494 (Secretary M. Roter)