Job ID: 12517

Post-doctoral position in Illkirch/France

Position: Post-doctoral Position

Deadline: 30 April 2021

Contract Length: 3 years renewable every year

City: Illkirch

Country: France

Institution: IGBMC

Department: Dpt Development and stem cells

Description:

Retinoid x receptor gamma (RXRg) acts as key positive regulator of remyelination in multiple sclerosis (MS), but the mechanisms of such activity are not known. Our published and new functional, and genomic data indicate that RXRg plays also an important role as a positive regulator of oligodendrocyte differentiation during development, the process which may involve some known but also new, previously unexpected pathways. The project will focus first on the validation of selected pathways and targets for their importance for oligodendrocyte differentiation and myelination process using siRNA, viral tools associated with transcriptomic analyses in vitro. In the second phase, in vivo validation will be carried out in dedicated existing and new genetic mouse models. The implications of such findings for understanding of MS pathophysiology and future treatments will be inferred from in vitro screens and the analysis of the EAE mouse model of MS.
Highly motivated candidates skilled in neurodevelopmental analyses of mice models and genomic or proteomic analysis are welcome to apply by sending one PDF document including motivation letter, CV with a list of publications, addresses of two scientists to provide references.

 

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